— Part 1 of a review of the Plant Positive video, How Much LDL?
There are 42 slides plus text in this video from Plant Positive. This post is intended merely as an index to these slides so that they can be referenced for discussion and located within the actual Plant Positive video. So, for each of Plant Positive’s slides, I have created a slide number and time position within the video. In addition, wherever the slide refers to 3rd party internet content, I added a source link.My index is in small blue italics and aligned with the left margin <– like this
A line or two of Plant Positive’s text (for the purpose of locating it in his video) is in green and is indented <– like this
======================================================Slide 0, 0:00 – Intro
In my Primitive Nutrition Series …Slide 1, 2:20 – Picture of cholesterol clogged artery
You’re looking at a cross section of an artery with a severe atheroma. …Slide 2, 3:00 – Analysis of arterial plaque composition
Have a look at this table showing how the lipid content …Slide 3, 3:25 – (journal) Atherosclerosis: The Road Ahead
This is why LDL is not just a mere risk factor, like any other biomarker. …Slide 4, 3:45 – (book) Nutritional and Metabolic Bases of CV Disease
This is made obvious by the unlucky one-in-a-million indivdual who is a homozygote for familial hypercholesterolemia, …Slide 5, 4:09 – (journal) Development of coronary heart disease in familial hypercholesterolemia
I’ve shown you already how heterozygotes …Slide 6, 4:24 – (book) The John Hopkins Textbook of Dyslipidemia
It is common knowledge that some people have a genetic tendency…Slide 7, 4:52 – (journal) Longevity syndromes: familial hypobeta and familial hyperalpha lipoproteinemia
One genetic condition that lowers LDL is called familial hypobeta …Slide 8, 5:06 – (journal) A meta-analysis of LDLc, non-HDLc, and apoB as markers of CV risk.
A specialist in cardiovascular disease may disagree with my focus on LDL. …Slide 9, 5:28 – (journal) 2009 Canadian LDL Tx guidelines
For the moment, LDL suits my purposes fine. …Slide 10, 5:35 – (journal) The Interrelationships of Serum Cholesterol, Cholesterol Esters and Phospholipids in Health and in CAD
Of course, high cholesterol is known to associate with heart disease …Slide 11, 5:53 – (journal) Relationship of Baseline Serum Cholesterol Levels in 3 Large Cohorts of Younger Men to Long-term Coronary, Cardiovascular, and All-Cause Mortality and to Longevity
This association between high cholesterol and heart disease …Slide 12, 6:20 – (Nobel lecture) A RECEPTOR-MEDIATED PATHWAY FOR CHOLESTEROL HOMEOSTASIS
One difficulty I have with the arguments of the cholesterol confusionists …Slide 13, 7:12 – (Mayo Clinic) High Cholesterol – Interpreting your cholesterol numbers
And yet low LDL, or what I would call LDL at the level the body needs …Slide 14, 7:34 – (journal) Primary prevention of coronary heart disease: integration of new data, evolving views, revised goals, and role of rosuvastatin in management. A comprehensive survey
Others beside Brown and Goldstein have explained why very low levels …Slide 15, 8:02 – (journal) Evidence Mandating Earlier and More Aggressive Treatment of Hypercholesterolemia
Daniel Steinberg, one of the foremost experts on cholesterol, …Slide 16, 8:27 – (popular press – USNWR): The Lipid Wars
John LaRosa, of the State University of New York Health Science Center …Slide 17, 8:38 – (journal) Primary prevention of coronary heart disease: integration of new data, evolving views, revised goals, and role of rosuvastatin in management. A comprehensive survey.
This is one reason why high risk patients are recommended by some …Slide 18, 8:50 – repeat of slide 13
The Mayo Clinic’s targets for LDL come from a revision …Slide 19, 9:06 – From the NCEP Third Report
But here’s what I find so strange. Read the original report …Slide 20, 9:26 – repeat of slide 13
Yet even the revised ATP targets call LDL from 100 to 129 near ideal. …Slide 21, 9:47 – From the NCEP Third Report
If they had known years earlier those levels were atherogenic? …Slide 22, 9:58 – (WAPF) The Skinny on Fats
The very low levels of LDL that are actually physiologically necessary …Slide 23, 10:24 – repeat of slide 1, picture of cholesterol clogged artery
Are they saying low cholesterol can cause this? …Slide 24, 10:31 – repeat of slide 22, (WAPF) The Skinny on Fats
And what about their police analogy? How many police officers …Slide 25, 26, 11:15 – (journal) Serum Cholesterol Concentration in New-Born African and European Infants and their Mothers
I thought this was a really interesting paper. …Slide 27, 28, 12:05 – (journal) Inflammation and cardiovascular disease mechanisms.
Those who argue for the false choice between cholesterol and inflammation …Slide 29, 13:19 – (journal) Evidence Mandating Earlier and More Aggressive Treatment of Hypercholesterolemia
Daniel Steinberg explains why inflammation is considered secondary …Slide 30, 13:50 – (journal) Dramatic remodeling of advanced atherosclerotic plaques of the apolipoprotein E-deficient mouse in a novel transplantation model
Steinberg references this amazing study. These scientists …Slide 31, 13:50 – (CJHP article) Current issues in Statin therapy: What’s up with lDl-cholesterol? and the lowdown on atherosclerosis Progression
There are those who say the reason the class of drugs called statins …Slide 32, 14:55 – From the NCEP Third Report
People who make this argument don’t remind you that the benefits …Slide 33, 15:06 – (journal) Overall mortality, incremental life expectancy, and cause of death at 25 years in the program on the surgical control of the hyperlipidemias
I’ll briefly remind you of the amazing work of Henry Buchwald, …Slide 34, 15:22 – (journal) Subendothelial lipoprotein retention as the initiating process in atherosclerosis: update and therapeutic implications.
Here is a really good journal article about atherosclerosis. …Slide 35, 15:51 – … continued
Here is another excerpt from this excellent article. …Slide 36, 16:44 – (journal) Regression and stabilization of advanced murine atherosclerotic lesions: a comparison of LDL lowering and HDL raising gene transfer strategies
This study came out after Steinberg wrote his article. Here, mice …Slide 37, 17:10 – … continued
A sustained low LDL condition induced dramatic healing of their arteries. …Slide 38, 17:34 – (Popular press – Science Daily) ‘Good’ HDL Cholesterol Can Also Be ‘Bad’
Low carbers often take false comfort in their high HDL numbers. …Slide 39, 18:02 – (journal) Effect of a short-term diet and exercise intervention on inflammatory/anti-inflammatory properties of HDL in overweight/obese men with cardiovascular risk factors.
If you want your HDL to be anti-inflammatory, …Slide 40, 18:10- (journal) Associations of coronary heart disease risk factors with the intermediate lesion of atherosclerosis in youth.
When you exclude the HDL number from your total cholesterol score, …Slide 41, 18:47 – (journal) Rapid regression of atherosclerosis: insights from the clinical and experimental literature.
It seems for dramatic healing of atherosclerosis to be possible, …Slide 42, 19:24- (journal) Is atherosclerotic vascular disease related to a high-fat diet?
Of course, the results of drug trials proved to be the most convincing …